RICT 2019

Interfacing Chemical Biology and Drug Discovery

55th International Conference on Medicinal Chemistry
55èmes Rencontres Internationales de Chimie Thérapeutique

 Nantes, France    July 3-5, 2019

Programme


07:30

Registration

08:30

RICT 2019 Opening

Prof. Sebastien PAPOT
UNIVERSITY OF POITIERS, Poitiers, France
Prof. Pascal MARCHAND
UNIVERSITY OF NANTES, Nantes, France
Dr Patricia LEMARCHAND
UNIVERSITY OF NANTES, Nantes, France

Inaugural Conference

Session Chair:

Prof. Sebastien PAPOT
UNIVERSITY OF POITIERS, Poitiers, France
09:00

PL01: What Makes a Great Medicinal Chemist: Some Fresh Thoughts

Dr Mark MURCKO
RELAY THERAPEUTICS, Boston, United States

Session 1: Recent Advances for Cancer Therapy

Session Chair:

Dr Yannick JACQUES
INSERM/CNRS, Nantes, France
09:45

PL02: Reprogramming the Reactivity of Iron in Cancer

Dr Raphaël RODRIGUEZ
INSTITUT CURIE, Paris, France
10:30

Coffee Break and Exhibition

11:00

PL03: Quo Vadis Small Molecule Cancer Therapeutics?

Dr Ingo HARTUNG
BAYER HEALTHCARE, Darmstadt, Germany
11:45

KL01: Therapeutic Potential of Macrocyclic ALK2 Inhibitors

Dr Pascal BENDERITTER
ONCODESIGN, Dijon, France
12:15

Lunch

13:00

Posters (Odd numbers) and Exhibition

Session 2: Artificial Intelligence in Drug Discovery

Session Chair:

Prof. Pascal BONNET
UNIVERSITY OF ORLÉANS, Orléans, France
14:30

PL04: Massively Multi-target Profile-QSAR: IC50 Predictions Comparable to 4-Concentration Experiments for most Novartis Assays

Dr Eric MARTIN
NOVARTIS, Emeryville, United States
15:15

PL05: Automated Syntheses Planning and its Implications for Drug Design

Dr Marwin SEGLER
BENEVOLENTAI, Cambridge, United Kingdom
16:00

Coffee Break and Exhibition

Session 3: Mechanism Based Approaches

Session Chair:

Dr Maria DUCA
UNIVERSITY OF CÔTE D'AZUR, Nice, France
16:30

PL06: Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 (SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA)

Dr Hasane RATNI
F. HOFFMANN-LA ROCHE LTD, Basel , Switzerland
17:15

PL07: The Influence of Free Ligand Conformations on Mcl-1 PPI Inhibition

Dr Rodrigo CARBAJO
ASTRAZENECA, Cambridge, United Kingdom
18:00

KL02: Tackling a Unique S1 Protease by SBDD - Highly Potent & Selective Factor D Inhibitors - Age-Related Macular Generation (AMD)

Dr Edwige LORTHIOIS
NOVARTIS, Basel, Switzerland
18:30

Welcome and Networking Reception

20:30

End of the day

Session 4: Paul Ehrlich Award Lecture (sponsored by Janssen Research & Development)

Session Chairs:

Dr Luc VAN HIJFTE
MERCACHEMSYNCOM, Nijmegen, The Netherlands
Dr Jose CID
JANSSEN R&D, Toledo, Spain
08:45

PL08: Paul Ehrlich Award Lecture - Chemotype - Phenotype - Target

Prof. Herbert WALDMANN
MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY, Dortmund, Germany

Session 5: New Breakthrough in Antibody-based Therapy

Session Chair:

Prof. Marie-Claude VIAUD-MASSUARD
FACULTÉ DES SCIENCES PHARMACEUTIQUES - UNIVERSITÉ DE TOURS, TOURS, France
09:45

PL09: Chemical Physiology of Antibody Conjugates and Natural Products

Prof. Gonçalo BERNARDES
INSTITUTO DE MEDICINA MOLECULAR, PORTUGAL & UNIVERSITY OF CAMBRIDGE, Cambridge, United Kingdom
10:30

Coffee Break and Exhibition

11:00

PL10: Click-Cleavable Antibody-Drug Conjugates

Dr Marc ROBILLARD
TAGWORKS PHARMACEUTICALS, Eindhoven, The Netherlands
11:45

PL11: Increasing Brain Exposure of Therapeutic Antibodies

Dr Dominique LESUISSE
SCT & SANOFI, Chilly-Mazarin, France
12:30

Lunch

13:00

Posters (Even numbers) and Exhibition

Session 6: Sugars in Drug Discovery

Session Chair:

Prof. Didier DUBREUIL
CEISAM - UNIVERSITY OF NANTES, Nantes, France
14:30

PL12: Carbohydrate-Lectin Interactions - What Makes Them Unique?

Prof. Dr Beat ERNST
UNIVERSITY OF BASEL, Basel, Switzerland
15:15

PL13: Complex Glycans in Health and Disease

Prof. Geert-Jan BOONS
UTRECHT UNIVERSITY, Utrecht, The Netherlands
16:00

Coffee Break and Exhibition

Session 7: New Modalities in Drug Discovery

Session Chair:

Prof. Pascal MARCHAND
UNIVERSITY OF NANTES, Nantes, France
16:30

PL14: Unlocking Drug Discovery Power through Collaborative Efforts between Academia and CRO : Bringing Novel Tankyrase Inhibitors towards the Clinic

Dr Anita WEGERT
MERCACHEM-SYNCOM, Nijmegen, The Netherlands
17:15

PL15: Identification of S 64315, a Potent and Selective Mcl-1 Inhibitor through Fragment-based Drug Discovery

Dr Andras KOTSCHY
SERVIER RESEARCH INSTITUTE OF MEDICINAL CHEMISTRY, Budapest, Hungary
18:00

KL03: Nanofitin Modules Platform: Go Multispecific, Go Multiparatopic !

Dr Anne CHEVREL
AFFILOGIC, Nantes, France
18:30

End of the day

20:30

Banquet

Session 8: New Tools for Therapeutic Innovation

Session Chair:

Prof. Joachim JOSE
UNIVERSITY OF MÜNSTER, Münster, Germany
08:30

PL16: Straightforward Conversion of Peptides into Bioactive Lactam-Based Foldamers

Prof. Muriel AMBLARD
CNRS-UNIVERSTY OF MONTPELLIER I, Montpellier, France
09:15

PL17: Chemical Biology of mRNA Modifications

Prof. Andrea RENTMEISTER
UNIVERSITY OF MÜNSTER, Münster, Germany
10:00

Coffee Break and Exhibition

Session 9: Modifying Proteins Structures and Functions

Session Chair:

Dr Gilles GUICHARD
UNIVERSITY OF BORDEAUX, Bordeaux, France
10:30

PL18: Modulating Different Components of the Ubiquitin System with Small Molecules and Cyclic Peptides

Prof. Ashraf BRIK
TECHNION-ISRAEL INSTITUTE OF TECHNOLOGY, Haifa, Israel
11:15

PL19: Cysteine Arylation to Engineer, Deliver, and Discover Proteins

Prof. Bradley Lether PENTELUTE
MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, MA, United States

Session 10: Pierre Fabre Award Lecture (Sponsored by Pierre Fabre)

Session Chairs:

Dr Serge GRISONI
CENTRE DE RECHERCHE ET DÉVELOPPEMENT PIERRE FABRE, Toulouse, France
Dr Brigitte LESUR
SCT & INSTITUT DE RECHERCHES SERVIER, Paris, France
12:00

PL20: Pierre Fabre Award Lecture - Click Chemistry with Mesoionics: New Tools for Chemical Biology

Dr Frédéric TARAN
CEA/SACLAY, Gif-sur-Yvette, France
13:00

Closing Remarks